Someone years ago shared with me the principle of "a happy wife leads to a happy life". I chuckled, acknowledged the sage advice, and stored the catch-phrase somewhere in my brain.  It wasn't until I started working with my wife Lilli as co-founder of EdgeOne Medical that I realized how true this saying was.  But it wasn't just about "happiness"--it was about something more.  It was about significance.  Her life's significance and what I could do to support and enable her pursuit of significance.